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Androgens such as Testosterone play a role in several aspects of male sexual behavior such as libido, erectile function, and orgasms. The need for a transdermal testosterone gel has arisen to overcome the disadvantages of other forms of the hormone for individuals. For example, injectable esters were associated with a high frequency of injection site reactions, and oral drugs were not absorbed by many without side effects.
In 2000, Testosterone gel became available for the treatment of male hypogonadism in the United States. Scientists have demonstrated that the use of the gel resulted in a significant increase in serum testosterone levels, with parallel and corresponding increases in serum dihydrotestosterone (DHT) and estradiol. After the first application of testosterone gel to hypo-gonadal men, serum testosterone levels rose to the normal range within 30 minutes and then gradually increased over the next 24 hours.
Testosterone gels mimic the natural release of testosterone in the body. Some men who use the gel for bodybuilding complain that testosterone gels do not fully raise testosterone levels to normal levels. With this being said, testosterone in gel form has benefits over the other forms of the hormone:
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