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DHT (Dihydrotestosterone) is the main androgen responsible for promoting androgenic alopecia (male pattern baldness). Therefore, steroids that convert into DHT within the body can cause this side effect for the steroid user. However, a group of drugs called reductase inhibitors can protect the user from androgenic side effects such as steroid-induced hair loss, oily skin and acne, by reducing the amount of DHT in the body.
Types of hair loss pills
There are currently two reductase inhibitors on the market today that are most popular with bodybuilders and athletes for the purpose of reducing hair loss due to the use of steroids. There are Finasteride and Dutasteride. These two drugs are similar in their action but one has a stronger effect than the other.
What is the most effective drug for hair loss?
Finasteride and Dutasteride have a comparable effect. Finasteride inhibits type 2 5-alpha reductase, while type 1 remains intact. Dutasteride inhibits both types of 5-alpha reductase, which can significantly improve the therapeutic effect, since the first type makes up approximately 30% of the total 5-alpha reductase. If in a particular person the first type of 5-alpha reductase is more active than the second type, or if the receptor sensitivity is high, then even these 30% percent can play a large role in the treatment of baldness.
The therapeutic effect of both drugs develops gradually over 6–12 months. Although, the concentration of both drugs in the prostate gland is the same about 85–90%, long-term treatment with Finasteride reduces the concentration of dihydrotestosterone in the blood by about 70%, and Dutasteride by 95%.
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